Wnt/β-连环蛋白信号通路在哺乳动物毛囊发育中的调控作用

doi:10.11843/j.issn.0366-6964.2019.11.002

摘要/Abstract

摘要： 毛囊是哺乳动物皮肤上重要附属结构，是控制被毛生长最重要的器官。毛囊发育主要包括毛囊形态发生以及毛囊再生。Wnt/β-连环蛋白（β-catenin）信号通路在毛囊发育中起重要作用，引起学者及研究机构的广泛关注。本文综述了Wnt/β-catenin信号通路调节机制和核内激活，Wnt/β-catenin对毛囊形态发生和毛囊再生的调控作用以及成骨细胞抑制因子（Dkk）和营养物质对毛囊发育的调控作用。为Wnt/β-catenin信号通路调控哺乳动物毛囊发育的研究提供借鉴。

Abstract: Hair follicles are important accessory structures on mammalian skin and are the most important organs for controlling hair growth. Development of hair follicle mainly includes hair follicle morphogenesis and hair follicle regeneration.The Wnt/β-catenin signaling pathway plays an important role in the development of hair follicle and has received extensive attention from scholars and research institutions. In this paper, regulating mechanisms and intranuclear activation of Wnt/β-catenin were reviewed. Regulating mechanisms of Wnt/β-catenin on hair follicle morphogenesis and hair follicle regeneration, regulatory roles of osteoblast inhibitory factor (Dkk) and a large number of nutrients on development of hair follicle in mammals were also summarized. The current review will provide references for the regulation of mammalian hair follicle development by Wnt/β-catenin signaling pathway.

中图分类号:

S852.21

李凡, 陈晓阳, 杨国雨, 李福昌. Wnt/β-连环蛋白信号通路在哺乳动物毛囊发育中的调控作用[J]. 畜牧兽医学报, 2019, 50(11): 2186-2194.

LI Fan, CHEN Xiaoyang, YANG Guoyu, LI Fuchang. The Regulatory Role of Wnt/β-catenin Signaling Pathway in the Development of Mammalian Hair Follicles[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2019, 50(11): 2186-2194.

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